Biography
Dr Luis Cristovao Porto has experience in cell and tissue biology, histocompatibility and clinical pathology and work mainly on the following topics: tissue repair, organ transplantation, hepatitis and laboratory medicine management.
Luis has participated in the concept and is a professor of the graduate program of human and experimental biology (master and doctoral) after returning from his doctoral studies. Since 1994, he has been head of the Laboratory of Histocompatibility and achieved the position of full professor in Universidade do Estado do Rio de Janeiro, Brazil, in 1999. Luis has the expertise, leadership, training, and motivation necessary to successfully carry out the proposed research project in its topics related to HLA and immune response in association to infection diseases. As PI or co-investigators, funded by Brazilian Research Agency, Health Ministry and Rio de Janeiro Research Agency Foundation, Luis contributed to the definition of HLA alleles and haplotypes associated with the susceptibility or protection of diseases and also in relation to vaccination of malaria and the HLA allele and haplotypes frequencies of the Brazilian Bone Marrow Registry.
Luis’s early publications directly addressed the presence of extracellular matrix proteins, more specifically collagen and elastic system fibres and their association with stages of diseases. In this context, both in liver fibrosis, saphenous veins varicosities and in skin diseases Luis has the chance to confirm and increment of knowledge of the disorganization, both qualitative and quantitative, of the “normal” complex macromolecular arrangement around hepatocytes, bile ducts, smooth muscle cells, fibroblasts, myofibroblasts and monocyte/macrophages in experimental animal models and human tissues. Luis maintained collaboration with colleagues that he supervised in their initial studies during doctoral studies in tissue repair and extracellular matrix, which implicates the cell modulation related to inflammation and oxidative stress.
Research interests: immunogenetics; immunology
Collaboration ideas:
- Establishment of a long-term partnership, with the possibility of greater exchange between researchers and training for doctoral and postdoctoral students.
- Evaluation: 1) of the amplitude and longevity of neutralizing responses, as well as antibody epitope profiles targeting VOCs/emerging mutations; 2) the roles of virus variants and the decline in immunity, allowing reinfections.
Website: https://www.researchgate.net/profile/luis-porto-5
ORCID ID: 0000-0003-1499-1821